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chondrotissue® | BioTissue

Zero handicap:
chondrotissue®, the implant for cartilage injuries in the knee, ankle, and hip.

chondrotissue®

Marrow stimulating techniques such as microfracturing or Pridie drilling are frequently used to treat cartilage defects.

Though they might help for very small defects without weight-bearing, clinical outcomes have shown that they are ineffective for the treatment of medium to bigger defects in the long term follow-up. They lead to fibrous repair tissue that will degenerate again under the effect of compression and shear forces.

chondrotissue_einleitung1_1

1- Bone marrow stimulation

chondrotissue_einleitung1_2

2- Bleeding an cell migration

chondrotissue_einleitung1_3

3- Formation of a fibrous repair tissue

Thus, a stable 3D scaffold is needed to:   

1 – correct disturbed biomechanical forces in the defect area (capping effect)
2 – home and keep in place migrating mesenchymal stem and progenitor cells
3 – trigger the formation of hyaline-like cartilage

chondrotissue_einleitung2_1

1a - Einsatz von chondrotissue®

chondrotissue_einleitung2_2

2a - Migration von Stamm-und Vorläuferzellen in das chondrotissue®

chondrotissue_einleitung2_3

3a - Bildung von hyalinartigem Reparaturgewebe

By covering the defect area with chondrotissue® after bone marrow stimulating methods, mesenchymal stem and progenitor cells migrate into and remain in the scaffold. Cells find an optimal stable 3D environment to form hyaline-like repair tissue.

The application of chondrotissue® improves the results obtained after standard bone marrow stimulation techniques.