Marrow stimulating techniques such as microfracturing or Pridie drilling are frequently used to treat cartilage defects.
Though they might help for very small defects without weight-bearing, clinical outcomes have shown that they are ineffective for the treatment of medium to bigger defects in the long term follow-up. They lead to fibrous repair tissue that will degenerate again under the effect of compression and shear forces.
Thus, a stable 3D scaffold is needed to:
1 – correct disturbed biomechanical forces in the defect area (capping effect)
2 – home and keep in place migrating mesenchymal stem and progenitor cells
3 – trigger the formation of hyaline-like cartilage
By covering the defect area with chondrotissue® after bone marrow stimulating methods, mesenchymal stem and progenitor cells migrate into and remain in the scaffold. Cells find an optimal stable 3D environment to form hyaline-like repair tissue.
The application of chondrotissue® improves the results obtained after standard bone marrow stimulation techniques.